Statistical and methodological consulting
Statistical and causal inference form the heart of scientific thinking in experimental sciences. They form the theoretical basis for the whole methodological corpus used in life sciences, from laboratory experimentation to large-scale epidemiological research. As such, they are a key to successful research. ClinSearch brings thorough and creative methodological thinking to your projects, from design to reporting time.
Every clinical investigation ends by the computation of a single statistical test or parameter that provides the answer to the primary study question. Performing such a test is usually trivial for any moderately skilled statistician. Ensuring that it yields a useful result, on the other hand, requires careful thinking, at study design time.
Indeed, most design choices have statistical implications: experimental design, evaluation criteria, subject selection criteria, follow-up modalities… Yet, these implications are often overlooked, leading many studies to end up underpowered, biased or otherwise hampered in their conclusions. Conversely, the choice of appropriate analytical methods requires the injection of clinical intelligence into statistical thinking.
ClinSearch consulting services integrate clinical, statistical and causal insight into your designs, especially in the following domains:
- Controlled trials,
- Cohorts and registries,
- Case-control and other retrospective studies,
- Surveys and polls,
- Meta analysis and systematic reviews,
- Diagnostic accuracy studies.
- Development and validation of questionnaires, scales and indexes.
Our offer, for your new projects, includes:
- Protocol design,
- Statistical review of protocols and case report forms (CRFs),
- Sample size evaluation,
- Design and implementation of randomisation or minimisation schemes,
- Statistical analysis planning (SAP),
- Database design,
- Data validation planning and programming.
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News
Morning Read: Non-profit designing free Wi-Fi architecture for hospitals >> Read
Managing retinal vein occlusion >> Read
Let Me Die on the Prairie by Frances Jane Crosby Van Alstyne >> Read
Publication: Volume 16, number 4 (Stevenson). Study found that no conclusive results can be provided on the cost-effectiveness of four non-invasive tests for liver fibrosis [the Enhanced Liver Fibrosis Test, FibroTest and FibroMAX and transient elastography (FibroScan)] in patients suspected of having alcohol-related liver disease. >> Read
Top headlines from HIMSS2012 (Tuesday edition) >> Read
Incidence of diabetic retinopathy in people with type 2 diabetes mellitus attending the Diabetic Retinopathy Screening Service for Wales: retrospective analysis >> Read
Publication: Volume 16, number 3 (Hockenhull). Report finds that whilst some interventions targeted at mental health populations to reduce violence are well supported by the evidence a scattergun approach in the research literature provides little firm evidence for the majority of interventions. Evidence shows small-to-moderate effects for cognitive behavioural therapy for psychological interventions, and larger effects for atypical antipsychotic drugs. >> Read
How the NHS measures up to other health systems >> Read
Publication: Volume 16, number 5 (Ara). Although orlistat, sibutramine and rimonabant are all effective at reducing weight and body mass index and, compared with placebo, are all cost-effective, both sibutramine and rimonabant have been withdrawn because of safety concerns relating to potential treatment-induced fatal adverse events. >> Read
Peter John Fenton >> Read
Publication: Volume 16, number 6 (Reeves). The verteporfin photodynamic therapy cohort study found that treatment and follow-up were much less frequent in routine clinical practice than in research trials and the cost-effectiveness was similar to the highest previous estimate. >> Read
Frederick Valentine Flynn >> Read